small molecule library (Selleck Chemicals)

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Selleck Chemicals small molecule library
Small Molecule Library, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 94/100, based on 73 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/small+bioactive+molecules/Bioactive+Compound+Library-%E2%85%A1/pmc13006433-355-31-35
Average 94 stars, based on 73 article reviews

small molecule library - by Bioz Stars, 2026-11

94/100 stars

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Drug discovery:

Article Title: Morphological profiling in human dopaminergic neurons identifies mitochondrial uncoupling as a neuroprotective effect
Article Snippet: The processes of plate coating, cell seeding, and medium changes were automated using an Bravo Automated Liquid Handling Platform with 384ST head (Agilent) and a Multidrop Combi Dispenser (ThermoFischer Scientific). .. 1,020 small molecules were selected from a bioactive compound library (Selleckchem), based on PD-relevant pathobiology, FDA approval status, and blood-brain-barrier penetrance ( Table S3 ). .. Prostratin treatment: Neurons were cultured until D33, treated with 5 μM Prostratin (Biotechne) or DMSO for 72 hours and immunofluorescently stained.

Article Title: Functional and pharmacological analyses of visual habituation learning in larval zebrafish
Article Snippet: .. The small-molecule compound library (Selleckchem Bioactive: FDA-approved/FDA-like small molecules ) was obtained from the UPenn High-Throughput Screening Core. ..

Article Title: Polo-like kinase inhibitors increase AAV production by halting cell cycle progression.
Article Snippet: .. A compound library of bioactive small molecules (Food and Drug Administration-approved and passed phase 1 drug library; Selleckchem, Houston, TX) was diluted to create a working library at a concentration of 10 mM. ..

Article Title: Polo-like kinase inhibitors increase AAV production by halting cell cycle progression
Article Snippet: .. A compound library of bioactive small molecules (Food and Drug Administration-approved and passed phase 1 drug library; Selleckchem, Houston, TX) was diluted to create a working library at a concentration of 10 μM. ..

Article Title: Functional and pharmacological analyses of visual habituation learning in larval zebrafish
Article Snippet: .. The small- molecule compound library (Selleckchem Bioactive: FDA- approved/FDA- like small molecules Figure 3—source data 1) was obtained from the UPenn High- Throughput Screening Core. ..

Article Title: Morphological profiling reveals neuroprotection via mitochondrial uncoupling in human dopaminergic neurons
Article Snippet: The processes of plate coating, cell seeding, and medium changes were automated using an Bravo Automated Liquid Handling Platform with 384ST head (Agilent) and a Multidrop Combi Dispenser (ThermoFischer Scientific). .. 1,020 small molecules were selected from a bioactive compound library (Selleckchem), based on PD-relevant pathobiology, FDA approval status, and blood-brain-barrier penetrance (Table ). .. Prostratin treatment : Neurons were cultured until D33, treated with 5 μM Prostratin (Biotechne) or DMSO for 72 h and immunofluorescently stained.

Fluorescence:

Article Title: Duloxetine ameliorates cerebral ischemic injury by inhibiting autophagy.
Article Snippet: To cite this article: Alice Viotti , Claudia Molinaro , Jessica Perego , Andrea Fossaghi , Chiara Parravicini , Eliana Laurenzano , Antonella Borreca , Marco Piccoli , Luigi Anastasia , Susanna Manenti , Annamaria Finardi , Alessandra Mandelli , Michela Matteoli , Ivano Eberini , Paola Panina , Gianvito Martino & Luca Muzio (05 Mar 2026): Duloxetine ameliorates cerebral ischemic injury by inhibiting autophagy, Autophagy, DOI: 10.1080/15548627.2026.2641616

In Vitro:

In Vivo:

Biomarker Discovery:

High Throughput Screening Assay:

Article Title: Functional and pharmacological analyses of visual habituation learning in larval zebrafish
Article Snippet: .. The small- molecule compound library (Selleckchem Bioactive: FDA- approved/FDA- like small molecules Figure 3—source data 1) was obtained from the UPenn High- Throughput Screening Core. ..

Food & Beverages:

Concentration Assay:

Cell Counting:

Article Title: Discovery of YH677 as a cancer stemness inhibitor that suppresses triple-negative breast cancer growth and metastasis by regulating the TGFβ signaling pathway.
Article Snippet: Triple-negative breast cancer (TNBC) has a poor prognosis due to the lack of specific and highly effective therapeutic agents.. Cancer stem cells (CSCs) are one of the main factors contributing to TNBC relapse and metastasis.. Therefore, targeting CSCs selectively with small molecules is a novel strategy for drug development.

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